The U.S. Patent & Trademark Office (USPTO) recently issued thirteen U.S. patents to UNM Rainforest Innovations during the months of October, November, and December for technologies invented at the University of New Mexico. The patents, issued during UNM Rainforest Innovations’ 2026 fiscal second quarter, are for a variety of technologies created by researchers in the Departments of Civil, Construction & Environmental Engineering; Chemical & Biological Engineering; Chemical & Nuclear Engineering; Electrical & Computer Engineering; Physics & Astronomy; Pathology; Anesthesiology; Obstetrics & Gynecology; the Center for Micro-Engineered Materials; and the Center for High Technology Materials.
Issued Patent for “Silicified Cell Replicas, Methods of Making, and Methods of Using”
Patent No. 12,433,940 issued on October 7, 2025
Inventors: Rita Serda, C. Jeffrey Brinker, Jacob Ongudi Agola, Jimin Guo, Sarah Adams
(Ref. 2017-090)
A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.
Issued Patent for “Compositions Comprising Antibodies or Antibody Fragments Which Bind the P2X4 Receptor”
Patent No. 12,448,440 issued on October 21, 2025
Inventors: Karin Westlund High, Ravi Venkata Durvasula, Adinarayana Kunamneni
This technology is currently optioned.
(Ref. 2020-008)
Described here is a composition for treating pain includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. In some embodiments, the receptor is a P2X family receptor such as, for example, P2X4. In some embodiments, the antibody includes a detectable marker. In some of these embodiments, the detectable marker includes a fluorescent tag. The composition may be used to treat acute or chronic pain in a subject. Generally, the methods includes administering to the subject a composition that includes an antibody or antibody fragment that specifically binds to a receptor involved in pain. The non-opioid pain relief composition can reverse pain related mechanical, cold, anxiety-like, and depression-like behaviors in neuropathic pain and chemotoxic nerve injury models.
Patent No. 12,456,813 issued on October 28, 2025
Inventors: Francesca Cavallo, Divya Prakash, Daniel W. van der Weide, Max G Lagally, Shiva Hajitabarmarznaki, Shelley S. Scott
(Ref. 2023-008)
An antenna comprising: input and output coaxial horn antennas coupled with a self-assembled helical slow-wave structure cradled in a groove in a silicon-on-insulator wafer.
Issued Patent for “Integrated Bound-Mode Spectral/Angular Sensors”
Patent No. 12,460,967 issued on November 4, 2025
Inventors: Steven R.J. Brueck, Alexander Neumann, Payman Zarkesh-Ha
(Ref. 2021-045)
An occupancy sensor covering a wide field in an integrated chip is disclosed. The occupancy sensor includes an array of grating coupled waveguide sensors wherein continuous wave (cw) signals monitor an ambient light field for dynamic changes on times scales of seconds, and high frequency signals map in three-dimensions of the space using time-of-flight (TOF) measurements, pixel level electronics that perform signal processing; array level electronics that perform additional signal processing; and communications and site level electronics that interface with actuators to respond to occupancy sensing.
Patent No. 12,467,868 issued on November 11, 2025
Inventors: Aaron K. Neumann, Anatoliy O. Pinchuk
(Ref. 2018-007)
Described here are highly sensitive assays for pathogen detection, identification, and/or analysis including, but not limited to, sensing of metabolite patterns associated with high-risk drug resistance phenotypes.
Issued Patent for “Rechargeable Electrochemical Devices and Methods for the Same”
Patent No. 12,482,843 issued on November 25, 2025
Inventors: Shuya Wei, Cameron Carugati, Christie Fetrow
This technology is currently licensed.
(Ref. 2022-079)
Rechargeable electrochemical devices and methods for the same are disclosed. The electrochemical devices may include an anode, a cathode, and an electrolyte disposed between the anode and the cathode. The electrolyte may include a deep eutectic mixture and an electrolyte additive. The deep eutectic mixture may include an ion coordinated complex prepared from a combination of aluminum chloride (AlCl.sub.3) and an amide or a combination of AlCl.sub.3 and an organic salt.
Issued Patent for “Salts of R-ketorolac”
Patent No. 12,492,206 issued on December 9, 2025
Inventors: Arthur Kluge, Emily Rigsbee, Ekaterina Albert
(Ref. 2025-068)
Salts of R-ketorolac, including solid salts, such as crystalline salts of the meglumine and tromethamine salts R-ketorolac, are disclosed. Methods of preparing such salts, pharmaceutical compositions comprising salts, and methods of treating cancer with such salts are further provided.
Issued Patent for “Method of Detecting Inherited Equine Myopathy”
Patent No. 12,497,659 issued on December 16, 2025
Inventors: Jeremy S. Edwards, Paul Szauter, Robert B. Sinclair
This technology is currently licensed.
(Ref. 2019-003)
This disclosure describes detecting genetically distinct kinds of inherited myopathies in horses, variously referred to as Polysaccharide Storage Myopathy type 2 (PSSM2), Myofibrillar Myopathy (MFM), or idiopathic myopathy.
Patent No. 12,500,386 issues on December 16, 2025
Inventors: Mansoor Sheik-Bahae, Alexander Albrecht, Jackson Kock, Azzurra Volpi
(Ref. 2021-075)
A laser cooling system and a method of laser cooling are disclosed. The laser cooling system includes a multi-pass optical cavity; a first mirror positioned at a first end of the multi-pass optical cavity; and a second mirror positioned at a second end of the multi-pass optical cavity, wherein the first mirror or the second mirror comprises a spectrally selective coating to suppress amplified spontaneous emission (ASE) and parasitic lasing to avoid undesired heat generation in a material being cooled in the multi-pass optical cavity.
Issued Patent for “Thin Film for Aqueous Electrochemical Heavy Metal Detection and Methods Thereof”
Patent No. 12,504,395 issued on December 23, 2025
Inventors: Tybur Casuse, Jose Cerrato Corrales, Fernando Garzon
(Ref. 2022-009)
Described here is a device for aqueous electrochemical analysis a sensor is disclosed, which may include a sensing electrode having a thin film surface, a counter electrode coupled to the sensing electrode, and a reference electrode coupled to the sensing electrode and the counter electrode. The device also includes where the thin film surface of the sensing electrode may include a uniaxial texture that is normal to a plane of the thin film surface. A method for aqueous electrochemical analysis is also disclosed, including exposing an aqueous sample to a sensor including a sensing electrode having a thin film surface, where the thin film surface of the sensing electrode may include a uniaxial texture that is normal to a plane of the thin film surface.
Issued Patent for “Lagrangian Smart Sensing System For Characterizing Aquatic Resources”
Patent No. 12,504,417 issued on December 23, 2025
Inventors: Aashish Khandelwal, Ricardo Gonzalez-Pinzon, Tzion Castillo
(Ref. 2023-005)
Techniques for large-scale Lagrangian monitoring of an aquatic resource are presented. The techniques use a system that includes an autonomous surface vehicle, where the autonomous surface vehicle includes: an electronic controller; a power source coupled to the electronic controller; a plurality of sensors communicatively coupled to the electronic controller, the plurality of sensors including: a water quality sensor and a GPS sensor; and a propulsion system communicatively coupled to the electronic controller, the propulsion system including a thruster and at least one rudder; where the system determines a velocity of water in the aquatic resource based on a plurality of position signals from the GPS sensor.
Patent No. 12,509,435, issued on December 30, 2025
Inventors: Eric R. Prossnitz, Jeffrey B. Arterburn, Cristian Bologa
(Ref. 2020-017)
The current invention is in the field of molecular biology/pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and/or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention/reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson’s disease and Alzheimer’s disease), as well as inflammatory bowel disease, Crohn’s disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.
Issued Patent for “Systems and Methods for Analyzing Stability using Metal Resistance Variations”
Patent No. 12,511,104, issued on December 30, 2025
Inventors: James Plusquellic
This technology is currently licensed.
(Ref. 2014-024)
This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.