UNM Rainforest Innovations

The U.S. Patent & Trademark Office (USPTO) recently issued eighteen U.S. patents to UNM Rainforest Innovations during the months of October, November, and December for technologies invented at the University of New Mexico. The patents, issued during UNM Rainforest Innovations’ 2021 fiscal second quarter, are for a variety of technologies created by researchers in the Departments of Neurology; Molecular Genetics & Microbiology; Pharmacy; Pharmaceutical Sciences; Internal Medicine – Translational Informatics; Pathology; Biochemistry & Molecular Biology; Chemistry; Language, Literacy, & Sociocultural Studies; Computer Science; Electrical & Computer Engineering; Chemical & Nuclear Engineering; Nanosciences & Microsystems; and Physics & Astronomy; the Center for Emerging Energy Technologies; the Center for High Technology Materials; the Center for Micro-Engineered Materials; and the Cancer Research & Treatment Center.

Issued Patent for “Hemorheologic Approach for Reduction/Prevention of Cancer Metastasis Formation”
Patent No. 10,792,304, issue date October 6, 2020
This technology is currently licensed.
Inventors: Marina V. Kameneva, Denis Bragin, Edwin Nemoto, Richard Simmons

Methods and compositions for the treatment, amelioration, or prevention of cancer and/or cancer metastasis by delivery of a hemodynamics altering agent such as a drag reducing polymer (DRP).

Issued Patent for “System and Methods for Computing 2-D Convolutions and Cross-Correlations
Patent No. 10,810,696, issue date October 20, 2020
Inventors: Marios S. Pattichis, Cesar Carranza, Daniel Llamocca Obregon

Fast and scalable architectures and methods adaptable to available resources, that (1) compute 2-D convolutions using 1-D convolutions, (2) provide fast transposition and accumulation of results for computing fast cross-correlations or 2-D convolutions, and (3) provide parallel computations using pipelined 1-D convolvers. Additionally, fast and scalable architectures and methods that compute 2-D linear convolutions using Discrete Periodic Radon Transforms (DPRTs) including the use of scalable DPRT, Fast DPRT, and fast 1-D convolutions.

Issued Patent for “Defrosting Infrared Windows using Transparent Metallic Nanostructures
Patent No. 10,813,175, issue date October 20, 2020
Inventors: Sang Eon Han

An optoelectronic device having a self-defrosting/de-icing window configured to operate at an electromagnetic radiation frequency having metals that are optically transparent as a result of the wires having an effective plasma frequency that is equal to or lower than the electromagnetic frequency at which the device operates. The effective plasma frequency of the wire is lowered by configuring the path of the wire between the terminal ends to be meandering, serpentine, U-shaped and in other non-linear configurations. The metal wires are resistively heated.

Issued Patent for “VLP-based Vaccines for Targeting Staphylococcus Aureus Secreted Virulence Factors
Patent No. 10,821,167, issue date November 3, 2020
Inventors: Pamela Hall, Bryce Chackerian, David S. Peabody, Seth Michael Daly, Bradley Owen Elmore, Kathleen Triplett

The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

Issued Patent for “Human GLUT5 Specific Inhibitors and Methods of Treatment
Patent No. 10,822,325, issue date November 3, 2020
Inventors: Tudor Oprea, Christian George Bologa, Oleg Ursu, Jun-Yong Choe, Cristina Iancu

The present invention relates to compounds which have been discovered to be potent ligands (inhibitors) of human GLUT5 (glucose transporter type 5), a facilitative glucose transporter that transports fructose, and their use as ligands assays which can uncover additional ligands of GLUT5, having the potential for being used as drugs. In addition, the present invention is directed to compounds, chemical compositions and methods for treating disease states and conditions which are mediated through GLUT5, including such disease states and conditions as GLUT5 deficiency syndrome, diabetes (type I and II), cancer, metabolic diseases including metabolic syndrome and fatty liver disease, among others.

Issued Patent for “Graphene Materials with Controlled Morphology
Patent No. 10,826,109, issue date November 3, 2020
Inventors: Alexey Serov, Plamen B. Atanassov, Nalin Andersen

Novel non-planar non-contiguous graphene structures and novel methods for forming the same. According to some embodiments the novel methods result in three-dimensional graphene structures. According to a further embodiment these three-dimensional graphene structures have a specific, controlled morphology. According to a still further method the novel method results in decoratable graphene sheets or three-dimensional graphene structures.

Issued Patent for “Fractional Anisotropy in MRI as an Indicator of Reversible Pathology
Patent No. 10,827,946, issue date November 10, 2020
Inventors: Shihoko Kimura-Ohba, Laurel Sillerud

The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.

Issued Patent for “Metal Phosphide Nanomaterials Prepared from Single Source Metal Amides
Patent No. 10,836,638, issue date November 17, 2020
Inventors: Richard Alan Kemp, Diane Dickie, Bernadette A. Hernandez-Sanchez, Timothy N. Lambert

The present invention provides a novel solution or route for metal phosphide (MP.sub.x) nanomaterials from the thermal decomposition of metal bis[bis(diisopropylphosphino)amide], M[N(PPri.sub.2).sub.2].sub.2, and/or single-source precursors. Synthetic routes to MP.sub.x nanomaterials may be used in energy applications including batteries, semiconductors, magnets, catalyst, lasers, inks, electrocatalysts and photodiodes.

Issued Patent for “Durable Polymer-Aerogel Based Superhydrophobic Coatings: A Composite Material
Patent No. 10,837,139, issue date November 17, 2020
Inventors: David J. Kissel, Charles Jeffrey Brinker

Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140.degree. and a contact angle hysteresis of less than about 1.degree.. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

Issued Patent for “Atomic Force Microscopy Based on Nanowire Tips for High Aspect Ratio Nanoscale Metrology/Confocal Microscopy
Patent No. 10,840,092, issue date November 17, 2020
Inventors: Tito Busani, Steven R.J. Brueck, Daniel Feezell, Mahmoud Behzadirad

Nanowires that may be utilized in microscopy, for example atomic force microscopy (AFM), as part of an AFM probe, as well as for other uses, are disclosed. The nanowires may be formed from a Group III nitride such as an epitaxial layer that may be or include gallium nitride, indium nitride, aluminum nitride, and an alloy of these materials. During use of the AFM probe to measure a topography of a test sample surface, the nanowire can activated and caused to lase and emit a light, thereby illuminating the surface with the light. In an implementation, the light can be collected by the AFM probe itself, for example through an optical fiber to which the nanowire is attached.

Issued Patent for: “Optimization Methods for Radiation Therapy Planning
Patent No. 10,850,122, issue date December 1, 2020
Inventors: Shuang Luan, Daniel Andres Riofrio Almeida

An optimization technique for use with radiation therapy planning that combines stochastic optimization techniques such as Particle Swarm Optimization (PSO) with deterministic techniques to solve for optimal and reliable locations for delivery of radiation doses to a targeted tumor while minimizing the radiation dose experienced by the surrounding critical structures such as normal tissues and organs.

Issued Patent for “System and Methods for Multiple-Place Swarm Foraging with Dynamic Depots
Patent No. 10,850,395, issue date December 1, 2020
Inventors: Melanie E. Moses, Joshua P. Hecker, Qi Lu

Teams of robots can be organized to collectively complete complex real-world tasks, for example collective foraging in which robots search for, pick up, and drop off targets in a collection zone. A dynamic multiple-place foraging algorithm (MPFAdynamic) is a scalable, flexible, and efficient algorithm for robot swarms to collect objects in unmapped environments. It achieves scalability through a decentralized architecture in which robots search without central control, and then return to mobile depots which provide collection and communication points. Mobile depots move closer to clusters of targets as robots discover them, which reduces robot transport time as well as collisions among robots. Flexibility is achieved by incorporating individual robot behaviors in which robots move and communicate in ways that mimic the foraging behaviors of ants. The MPFAdynamic algorithm demonstrates that dispersed agents that dynamically adapt to local information in their environment provide more flexible and scalable swarms.

Issued Patent for “Distributed Pattern Matching Over Streaming Time Series
Patent No. 10,853,372, issue date December 1, 2020
Inventors: Abdullah Mueen, Hossein Hamooni

This disclosure describes technologies for pattern matching in data streams. Given one or more patterns of data, and one or more data streams, e.g., streams of measurements made by one or more sensors, this disclosure provides apparatus and techniques for identifying occurrences of the patterns in the data streams. Techniques according to this disclosure generally make use of distribution strategies, as disclosed herein, to distribute the work of pattern identification among multiple processors. Data streams may be divided into multiple segments, and patterns for identification as well as data stream segments may be distributed among the multiple processors.

Issued Patent for “Modulators of GTPases and Their Use”
Patent No. 10,857,130, issue date December 8, 2020
This technology is currently licensed.
Inventors: Angela Wandinger-Ness, Laurie Hudson, Larry Sklar, Zurab Surviladze, Tudor Oprea

The present invention relates to molecules which function as modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases (e.g. Rac, Cdc42 and Rho GTPases) and their use to treat diseases, including cancers (including solid tumors-medulloblastoma, ovarian, breast, head and neck, testicular, prostate among others and hematologic malignancies-B cell lymphoma, where these GTPases are overexpressed or hyperactivated), sporadic and genetic diseases where activation of Rho GTPases plays a pivotal role (Menkes disease, rheumatoid arthritis, atherosclerosis, diabetes (type I), Huntington’s disease and Alzheimer’s disease) which are mediated through these proteins. Compounds according to the present invention may also be used as a therapy for the treatment of Entamoeba spp. or Acanthamoeba spp. infections, especially including Entamoeba histolytica.

Issued Patent for “Graphene-based Inorganic-Organic Hybrid Materials and Separation of Racemic Mixtures
Patent No. 10,864,460, issue date December 15, 2020
Inventors: Alexey Serov, Plamen B. Atanassov, Nikolai Kalugin, Liliya V. Frolova

A variety of inorganic-organic hybrid materials and various methods for preparing and using the same are described. The hybrid materials are graphene or graphitic materials populated with organic molecules and may have a variety of surface defects, pits or three-dimensional architecture, thereby increasing the surface area of the material. The hybrid materials may take the form of three dimensional graphene nanosheets (3D GNS). If the organic molecules are enantiospecific molecules, the hybrid materials can be used for chiral separation of racemic mixtures.

Issued Patent for “Systems and Methods for Leveraging Path Delay Variations in a Circuit and Generating Error-Tolerant Bitstrings”
Patent No. 10,868,535, issue date December 15, 2020
This technology is currently licensed.
Inventors: James Plusquellic, James Aarestad

A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

Issued Patent for “Molecular Tracers and Modified Proppants for Monitoring Underground Fluid Flows”
Patent No. 10,871,066, issue date December 22, 2020
Inventors: Richard Kemp, Timothy Boyle

The present invention relates to modified proppants and methods of using the modified proppants that use metal ligand tracers to characterize subterranean fluid flow. The metal and ligands are best chosen to be a strongly-coordinating, chelating ligand with a functional group for the chosen flow environment.

Issued Patent for “High Throughput Characterization of Individual Magnetic Nanoparticles
Patent No. 10,875,766, issue date December 29, 2020
Inventors: Victor M. Acosta, Andrey Jarmola

Technologies related to parallel characterization of individual MNPs are disclosed. A diamond chip with MNPs distributed thereon may be used with an epifluorescence microscope and camera to generate multiple different images of multiple individual MNPs. The multiple images are recorded at different microwave frequencies and under different external magnetic field strengths. The multiple images are then used to determine properties of the multiple individual MNPs.

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