The U.S. Patent & Trademark Office (USPTO) recently issued twelve U.S. patents to UNM Rainforest Innovations during the months of April, May, and June for technologies invented at the University of New Mexico. The patents, issued during UNM Rainforest Innovations’ 2025 fiscal year fourth quarter, are for a variety of technologies created by researchers in the Departments of Internal Medicine; Emergency Medicine; Pathology; Cancer Research & Treatment Center; Pharmaceutical Sciences; Molecular Genetics & Microbiology; Chemical & Biological Engineering; Computer Science; Electrical & Computer Engineering; the Comprehensive Cancer Center; the Center for High Technology Materials; and the Center for Micro-Engineered Materials.
Issued Patent for “Filovirus Antibodies and Methods”
Patent No. 12,265,081, issued April 1, 2025
Inventors: Ravi Durvasula, Steven Bradfute, Adinarayana Kunamneni
(Ref. 2016-064)
An antibody that binds to a filovirus glycoprotein generally includes include a complementarity determining region (CDR) of any one of SEQ ID NO:27-36 or a combination of such CDRs. The antibody may be used in to detect filovirus in a biological sample obtained from a subject. The antibody also may be formulated into a pharmaceutical composition for administering to a subject having, or at risk of having, a filovirus infection.
Issued Patent for “Color Changing Detection Patch utilizing Microneedle Sampling of Interstitial Fluid”
Patent No. 12,279,861, issued April 22, 2025
Inventors: Robert Taylor, Justin T. Baca
(Ref. 2018-003)
Described here is a wearable device that is applied to the skin of a user (e.g., patient), samples the user’s interstitial fluid (IF), and indicates the presence or absence of a target substance. The device may further include a mechanism to ensure compliance and/or provide tamper resistance.
Issued Patent for “Novel Method to Separate Isotopes Created by Photonuclear Reactions”
Patent No. 12,283,388, issued April 22, 2025
Inventors: Alexey Serov, Douglas Wells, Nikolai Kalugin
(Ref. 2018-078)
The widespread utilization and growing demand for radiopharmaceuticals are attributable to the development and availability of a range of radiopharmaceuticals. The present disclosure describes methods of making 3-dimensional nano-porous, micro-porous, meso-porous, or macro-porous materials. The present disclosure also describes methods of irradiating and separating isotopes using the 3-dimensional nano-porous, micro-porous, meso-porous, or macro-porous materials.
Patent No. 12,285,470, issued April 29, 2025
Inventors: Vojo Deretic
(Ref. 2016-096)
The present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and/or TRIM 51 (preferably TRIM 16) and galectins, especially galectins 3 m order to influence autophagy and treat a number of disease states and/or conditions which are mediated and/or influenced by autophagy, including inflammatory disease states and/or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer.
Issued Patent for “Thermally Gelling Drug Formulations”
Patent No. 12,285,522, issued April 29, 2025
Inventors: Jason Thomas McConville
(Ref. 2019-042)
Orodispersible films (ODFs) and methods for making the same. ODFs are formed using a solvent casting technique wherein a mixture comprising a thermos-responsive polymer, an active pharmaceutical ingredient (API) and any optional excipients or other ingredients are cast at a temperature at or above the thermal gelation point of the mixture to form a stable gel, the solvent in the gel is then evaporated to produce a thin film.
Issued Patent for “Adjustable Multi-Slit Collimators”
Patent No. 12,285,631, issued April 29, 2025
Inventors: Richard Shaw, Shuang Luan
(Ref. 2017-077)
The transverse intensity distribution of a beam of x-rays or other radiation can be modulated with a multi-slit collimator device that includes one or more sets of collimator leaves arranged in a one-dimensional array and individually movable to form slits of variable width between pairs of adjacent collimator leaves. A two-dimensional intensity distribution may be achieved using multiple sets of one-dimensionally arranged leaves, e.g., by stacking them along the beam in different orientations, or by stacking them in a transverse direction to form a two-dimensional array of leaves. In some embodiments, the multi-slit collimator device also serves beam-monitoring purposes.
Patent No. 12,287,571, issued April 29, 2025
Inventors: Steven R.J. Brueck, Alexander K. Raub
(Ref. 2011-042)
In accordance with some aspects of the present disclosure, a maskless interferometric lithography system for fabricating a three-dimensional (3D) photonic crystal using a multiple two-beam-exposures is disclosed. The system can comprise an illumination system comprising an optical arrangement operable to receive radiation from a radiation source and provide three or more tilted two-beam interference pattern exposures to be combined into a three-dimensional pattern; and a substrate operable to be supported by a substrate table, wherein the substrate comprises a photoresist formed on a top surface of the substrate and operable to receive the three-dimensional pattern and wherein means are provided to adjust the position of the substrate in all six mechanical degrees of freedom.
Issued Patent for “Universal Laser Protective Eyewear”
Patent No. 12,290,475, issued May 6, 2025
Inventors: Masahiro Kamei, Tito Busani
(Ref. 2022-075)
A laser eye protection device is described that includes an optically opaque screen that covers both eyes; one or more internal viewing screens on an eye-facing side of the optically opaque screen; and one or more cameras arranged around the optically opaque screen, wherein the one or more cameras are in electrical and data communication with the one or more internal viewing screens and provide a visual representation of surroundings to a user.
Patent No. 12,298,305, issued May 13, 2025
Inventors: Tione Buranda, Jacob Ongudi Agola, Soumik BasuRay, Scarlett Swanson, Angela Wandinger-Ness, Peter C. Simons, Virginie Bondu
(Ref. 2013-061)
The invention provides a method of diagnosing sepsis or a virus-related infection (often a viral hemorrhagic fever infection) in a subject by detecting and measuring the level of a set of sepsis and virus infection-associated-GTPase biomarkers in a sample obtained from the subject using multiplexed flow cytometry. Related kits are also provided. In a preferred embodiment, the invention provides point of care diagnostic methods for determining an early stage sepsis or the severity of a virus infection, especially in a hospital or other setting.
Patent No. 12,308,615, issued May 20, 2025
Inventors: Daniel Feezell, Morteza Monavarian, Saadat M. Mishkat-Ul-Masabih
(Ref. 2020-080)
An electrically injected vertical-cavity surface emitting laser (VCSEL) and a method of manufacturing the same is disclosed. The electrically injected VCSEL includes a non-c-plane substrate and a nanoporous bottom distributed Bragg reflector (DBR) comprising a plurality of alternating highly doped III-nitride layers and unintentionally doped III-nitride layers formed above the substrate.
Issued Patent for “Split Source Drain Transistor”
Patent No. 12,322,712, issued June 3, 2025
Inventors: Joshua Joseph Trujillo, Payman Zarkesh-Ha
(Ref. 2023-022)
Systems, methods, circuits, and devices for providing and using transistors in a physically unclonable function (PUF) circuit. The transistors comprise a split source drain configuration including one or more inflection segments that increase process variations between the transistors such that each transistor generates a unique output signal.
Patent No. 12,328,913, issued June 10, 2025
Inventors: Francesca Cavallo, Mengistie Debasu, Max G. Lagally, Emma J. Renteria, Finley Haines
(Ref. 2021-068)
A semiconductor spintronic device is disclosed, which includes a substrate, a first ferromagnetic contact layer and a second ferromagnetic contact layer disposed on the substrate, and a semiconductor nanomembrane, disposed between the first ferromagnetic contact layer and the second ferromagnetic contact layer. The semiconductor spintronic device can include a screw dislocation throughout the thickness of the semiconductor nanomembrane layers. Methods of fabricating and operating a semiconductor spintronic device are also disclosed.